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KMID : 0617320030120010201
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Journal of Pharmacetical Sceiences Ewha Womans University
2003 Volume.12 No. 1 p.201 ~ p.212
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Gender Differences in the Membrane Transport of Endogenous and Exogenous Compounds
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MORRIS, MARILYN E.
LEE, HWA-JEONG/PREDKO, LISA M.
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Abstract
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Gender differences have been well described in pharmacokinetics and contribute to the interindividual variation in drug disposition, therapeutic response, and drug toxicity. Sex-related differences in the membrane transport of endogenous substrates and xenobiotics have been reported in various organs of the body including kidney, liver, intestine, and brain. These gender-related differences in transport systems could also contribute to interindividual variability in pharmacokinetics and pharmacodynamics. This review will focus on current knowledge of gender-associated differences in the transport of endogenous and exogenous compounds in a variety of body organs and will discuss the implications and the clinical significance of these observations.
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KEYWORD
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